
Get to know PETAL Consortium’s previous Clinical Research Coordinator, Caroline MacVicar!
Get to know PETAL Consortium’s previous Clinical Research Coordinator, Caroline MacVicar!
Get to know PETAL Consortium’s previous Clinical Research Coordinator, Caroline MacVicar!
By Emmanuel Nwodo
By Emmanuel Nwodo



Caroline MacVicar
Caroline MacVicar was a Clinical Research Coordinator at Massachusetts General Hospital. She earned her bachelor's degree in Biological Sciences from Wellesley College. She was a volunteer at the Newton-Wellesley Hospital and was an undergraduate research assistant in a microbiology lab at Wellesley. She is now an incoming first year medical student in the Army at Uniformed Services University!
Caroline MacVicar was a Clinical Research Coordinator at Massachusetts General Hospital. She earned her bachelor's degree in Biological Sciences from Wellesley College. She was a volunteer at the Newton-Wellesley Hospital and was an undergraduate research assistant in a microbiology lab at Wellesley. She is now an incoming first year medical student in the Army at Uniformed Services University!
In this Q&A, meet Caroline MacVicar, PETAL Consortium’s previous Clinical Research Coordinator!
In this Q&A, meet Caroline MacVicar, PETAL Consortium’s previous Clinical Research Coordinator!
In this Q&A, meet Caroline MacVicar, PETAL Consortium’s previous Clinical Research Coordinator!
Why do you want to become a doctor?
Why do you want to become a doctor?
When I was fourteen, my grandmother was diagnosed with Alzheimer’s disease. Seeing her distressed and struggling was heart-wrenching, and I often felt powerless to help. Throughout it all, her physician was a lifeline for our whole family, teaching us how to redirect my grandmother’s agitation by eliciting pleasant, long-term memories of her childhood in Canada. Although there was no way to alter the progression of my grandmother’s illness, her physician’s compassion and steady presence made a lasting impact on me. Despite the emotional challenges of the doctor’s profession, I admired his remarkable resilience and ability to focus on what he could control. He inspired my first thoughts of pursuing a career in medicine. The lifelong learning and critical-thinking skills inherent in medicine further confirmed my desire to pursue a career as a physician.
When I was fourteen, my grandmother was diagnosed with Alzheimer’s disease. Seeing her distressed and struggling was heart-wrenching, and I often felt powerless to help. Throughout it all, her physician was a lifeline for our whole family, teaching us how to redirect my grandmother’s agitation by eliciting pleasant, long-term memories of her childhood in Canada. Although there was no way to alter the progression of my grandmother’s illness, her physician’s compassion and steady presence made a lasting impact on me. Despite the emotional challenges of the doctor’s profession, I admired his remarkable resilience and ability to focus on what he could control. He inspired my first thoughts of pursuing a career in medicine. The lifelong learning and critical-thinking skills inherent in medicine further confirmed my desire to pursue a career as a physician.
Why did you major in Biological Sciences in college?
Why did you major in Biological Sciences in college?
I’ve always leaned toward STEM in general. I initially chose to major in Biological Sciences because I was considering a future career in medicine. I was passionate about human health and the environment, and I thought Biological Sciences was the best fit for my interests. Classes in plant, marine, and animal biology intersected with my environmental interests; cellular biology and microbiology were directly relevant to my human biology interests. Understanding the complexities of life was appealing to me.
I’ve always leaned toward STEM in general. I initially chose to major in Biological Sciences because I was considering a future career in medicine. I was passionate about human health and the environment, and I thought Biological Sciences was the best fit for my interests. Classes in plant, marine, and animal biology intersected with my environmental interests; cellular biology and microbiology were directly relevant to my human biology interests. Understanding the complexities of life was appealing to me.
What inspired you to go into medical research?
What inspired you to go into medical research?
Before my senior year of college, I interned in a neuroendocrine cancer research lab. It was my first time working in a medical research setting, and I loved it. I’d previously been in an environmental microbiology lab, which I enjoyed. However, this research had a direct connection to patient care, which felt more gratifying to me. That experience led me to pursue clinical and translational research, which takes scientific discoveries and puts them into practical clinical applications and ultimately brought me to work on T-cell lymphoma with PETAL.
Before my senior year of college, I interned in a neuroendocrine cancer research lab. It was my first time working in a medical research setting, and I loved it. I’d previously been in an environmental microbiology lab, which I enjoyed. However, this research had a direct connection to patient care, which felt more gratifying to me. That experience led me to pursue clinical and translational research, which takes scientific discoveries and puts them into practical clinical applications and ultimately brought me to work on T-cell lymphoma with PETAL.
What was your main research project with PETAL?
What was your main research project with PETAL?
My primary research in the wet lab focused on understanding how T-cell lymphoma starts and develops. I specifically studied how enhancers (short regions of DNA that increase transcription of specific genes) and super enhancers (enhancers that work harder) affect post-translational histone modifications (chemical changes that affect how tightly DNA wraps around histone proteins). In the clinic, I was part of the team that consented patients, collected biospecimen samples (tissues and saliva taken from patients), and helped coordinate research efforts.
My primary research in the wet lab focused on understanding how T-cell lymphoma starts and develops. I specifically studied how enhancers (short regions of DNA that increase transcription of specific genes) and super enhancers (enhancers that work harder) affect post-translational histone modifications (chemical changes that affect how tightly DNA wraps around histone proteins). In the clinic, I was part of the team that consented patients, collected biospecimen samples (tissues and saliva taken from patients), and helped coordinate research efforts.
What did a week-in-your-life at PETAL Consortium look like?
What did a week-in-your-life at PETAL Consortium look like?
In the lab, I performed CUT & Tag or CUT & RUN protocols, which identify enhancers and super-enhancers by tagging and cutting where there are post-translational histone modifications within the DNA of T-cell lymphoma cell lines and cells from mouse models. I also maintained various T-cell lymphoma cell lines by managing the nutrients of the cultured cells. I also performed RNA extractions to study gene expression and therefore potential enhancer/super-enhancer gene targets in various T-cell lymphoma cell lines and mouse models. I occasionally helped with biospecimen processing too.
In the clinic, I consented and enrolled patients to our various research studies, including PETAL. I also performed patient chart reviews and organized biospecimen collection.
In the lab, I performed CUT & Tag or CUT & RUN protocols, which identify enhancers and super-enhancers by tagging and cutting where there are post-translational histone modifications within the DNA of T-cell lymphoma cell lines and cells from mouse models. I also maintained various T-cell lymphoma cell lines by managing the nutrients of the cultured cells. I also performed RNA extractions to study gene expression and therefore potential enhancer/super-enhancer gene targets in various T-cell lymphoma cell lines and mouse models. I occasionally helped with biospecimen processing too.
In the clinic, I consented and enrolled patients to our various research studies, including PETAL. I also performed patient chart reviews and organized biospecimen collection.
Any interests/hobbies?
Any interests/hobbies?
I’m training for a 10-mile race right now. I’ve gotten up to four miles so far, so I’m building up slowly but surely. I also enjoy reading any good book!
I’m training for a 10-mile race right now. I’ve gotten up to four miles so far, so I’m building up slowly but surely. I also enjoy reading any good book!
Dream vacation destination?
Dream vacation destination?
Somewhere where I can do outdoor activities. I’ve always wanted to go to Switzerland. I love the mountains, hiking, and just being out in nature!
Somewhere where I can do outdoor activities. I’ve always wanted to go to Switzerland. I love the mountains, hiking, and just being out in nature!
Favorite meal?
Favorite meal?
I’d have to go with Mexican food. I love street tacos, especially chicken street tacos or carne asada with some chips and salsa on the side.
I’d have to go with Mexican food. I love street tacos, especially chicken street tacos or carne asada with some chips and salsa on the side.
Favorite TV shows/movies?
Favorite TV shows/movies?
My favorite movie is Glory, which is set during the Civil War and tells the story of the 54th Massachusetts Regiment, the first Black regiment in the U.S. Army. It’s even more meaningful to me because their monument stands just steps from where I currently live. For my favorite TV show, I’d say Game of Thrones because it was unpredictable.
My favorite movie is Glory, which is set during the Civil War and tells the story of the 54th Massachusetts Regiment, the first Black regiment in the U.S. Army. It’s even more meaningful to me because their monument stands just steps from where I currently live. For my favorite TV show, I’d say Game of Thrones because it was unpredictable.
Any pets?
I have a rescue dog named Bodhi (pictured on the right). He’s a Weimaraner, and he was named after Patrick Swayze’s character in Point Break. I also have a goldfish that’s somehow still alive after 17 years.
Any pets?
I have a rescue dog named Bodhi (pictured on the right). He’s a Weimaraner, and he was named after Patrick Swayze’s character in Point Break. I also have a goldfish that’s somehow still alive after 17 years.


Since we’re PETAL Consortium, favorite flower?
Since we’re PETAL Consortium, favorite flower?
Snapdragons and hydrangeas!
Snapdragons and hydrangeas!
@2025 PETAL Consortium • All rights reserved
@2025 PETAL Consortium • All rights reserved
@2025 PETAL Consortium • All rights reserved